Benzylamine → HCID 178450793, compound

HRID 1595320Notes

Reaction equation

HRID 1595320 reaction equation
O[N:2]=[C:3]([C:11](=O)[C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[C:20]1([C:19]2[NH:26][C:11]([C:12]3[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=3)=[C:3]([C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[N:2]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 178451309HCID 178451309, compound

Product 1

HCID 178450793HCID 178450793, compoundYield 41.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

tert-Butyl 2-hydroxyimino-3-oxo-3-(3-pyridyl)propionate (4.1 g), benzylamine (3.5 g) and acetonitrile (80 ml) were reacted and treated in the same manner as in Starting Material Synthetic Example 5 to give tert-butyl 2-phenyl-5-(3-pyridyl)imidazole-4-carboxylate (2.2 g), melting point 196-197° C.

Workup

  1. additiontreated in the same manner as

Sources & evidence

ORD record
ord-3608a990c9574e10b344e6e0b52131be
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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