Benzylamine → HCID 178450792, compound

HRID 1595321Notes

Reaction equation

HRID 1595321 reaction equation
O[N:2]=[C:3]([C:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[C:20]1([C:19]2[NH:26][C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[C:3]([C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[N:2]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 178451308HCID 178451308, compound

Product 1

HCID 178450792HCID 178450792, compoundYield 23.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

tert-Butyl 2-hydroxyimino-3-oxo-3-(2-pyridyl)propionate (6.0 g) and benzylamine (5.7 g) were dissolved in acetonitrile (100 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 5 to give tert-butyl 2-phenyl-5-(2-pyridyl)imidazole-4-carboxylate (1.8 g), melting point 211-213° C.

Workup

  1. customthe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-b38163353d234f67a7d33d03d172361f
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

Loading…