Sodium Hydroxide → HCID 178489908, compound

HRID 1595350Notes

Reaction equation

HRID 1595350 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([O:25]CC)=[O:24])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[NH:13][C:12]([C:14]3[CH:15]=[CH:16][C:17]([N+:20]([O-:22])=[O:21])=[CH:18][CH:19]=3)=[N:11][C:10]=2[C:23]([OH:25])=[O:24])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178470206HCID 178470206, compound

Product 1

HCID 178489908HCID 178489908, compoundYield 101.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 5-(3-methoxyphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylate (45.1 g) was dissolved in ethanol. 1 M Sodium hydroxide solution was added and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 2 to give 5-(3-methoxyphenyl)-2-(4-nitrophenyl)imidazole-4-carboxylic acid (42.1 g), melting point 116-118° C. (decomposition).

Workup

  1. customthe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-77b486001fcf456aa72eaadaeeb135fe
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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