4-Nitrobenzylamine → HCID 178475836, compound

HRID 1595357Notes

Reaction equation

[C:1]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=O)[C:13](=[N:21]O)[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[N+:24]([C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=1)([O-:26])=[O:25]>>[C:1]([O:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[NH:32][C:31]([C:30]3[CH:29]=[CH:28][C:27]([N+:24]([O-:26])=[O:25])=[CH:34][CH:33]=3)=[N:21][C:13]=2[C:14]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:15])=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 291474-Nitrobenzylamine

HCID 178475845HCID 178475845, compound

Product 1

HCID 178475836HCID 178475836, compoundYield 15.3%

Procedure

tert-Butyl 3-(4-acetoxymethylphenyl)-2-hydroxyimino-3-oxopropionate (33.9 g) and 4-nitrobenzylamine (19.3 g) were reacted and treated in the same manner as in Starting Material Synthetic Example 1 to give tert-butyl 5-(4-acetoxymethylphenyl)-2-(4-nitrophenyl)-imidazole-4-carboxylate (7.07 g), melting point 178-180° C. (decomposition).

Workup

additiontreated in the same manner as

Sources & evidence

ORD record: ord-df777a481833423a9b5741e764222159
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06288061B1

Reaction notes

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