Sodium Sulfate → N-(4-(hydroxymethyl)benzyl)acetamide

HRID 1595373노트

반응식

HRID 1595373 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([NH:10][CH2:11][C:12]1[CH:21]=[CH:20][C:15]([C:16](OC)=[O:17])=[CH:14][CH:13]=1)(=[O:9])[CH3:8].S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[OH:17][CH2:16][C:15]1[CH:20]=[CH:21][C:12]([CH2:11][NH:10][C:7](=[O:9])[CH3:8])=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 24436Sodium SulfateHCID 15550681Methyl 4-(acetamidomethyl)benzoateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 15550683N-(4-(hydroxymethyl)benzyl)acetamide수율 104.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a suspension of lithium aluminum hydride (570 mg) in THF (80 ml) was added a solution of methyl 4-acetamidomethylbenzoate (3.1 g) in THF (20 ml) under ice-cooling. The reaction mixture was stirred at room temperature for 1.5 hr. A saturated aqueous sodium sulfate solution (7 ml) was added at 10° C., and the mixture was stirred at room temperature for 1 hr. The precipitate was collected by filtration and the solvent was evaporated to give the objective N-(4-hydroxymethylphenylmethyl)acetamide (2.8 g) as a white solid.

후처리

  1. temperaturecooling
  2. stirringthe mixture was stirred at room temperature for 1 hr
  3. filtrationThe precipitate was collected by filtration
  4. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-f0494b2818f748df953bacc5287345f5
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

반응 노트

불러오는 중…