Sodium Sulfate → N-(4-(hydroxymethyl)benzyl)acetamide

Beteiligte Stoffe

Reaktionsschritte

To a suspension of lithium aluminum hydride (570 mg) in THF (80 ml) was added a solution of methyl 4-acetamidomethylbenzoate (3.1 g) in THF (20 ml) under ice-cooling. The reaction mixture was stirred at room temperature for 1.5 hr. A saturated aqueous sodium sulfate solution (7 ml) was added at 10° C., and the mixture was stirred at room temperature for 1 hr. The precipitate was collected by filtration and the solvent was evaporated to give the objective N-(4-hydroxymethylphenylmethyl)acetamide (2.8 g) as a white solid.

Herkunft & Nachweise