N-(4-Morpholinomethylphenylmethyl)acetamide hydrochloride → [4-(Morpholin-4-ylmethyl)phenyl]methanamine

HRID 1595375노트

반응식

HRID 1595375 반응식
Cl.[O:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][NH:16]C(=O)C)=[CH:11][CH:10]=2)[CH2:4][CH2:3]1>Cl>[O:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][NH2:16])=[CH:11][CH:10]=2)[CH2:4][CH2:3]1

참가 물질

3

반응물 1

HCID 21703892N-(4-Morpholinomethylphenylmethyl)acetamide hydrochloride

생성물 1

HCID 2795501[4-(Morpholin-4-ylmethyl)phenyl]methanamine수율 84.6%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

N-(4-Morpholinomethylphenylmethyl)acetamide hydrochloride (28.4 g) was dissolved in 4N hydrochloric acid (114 ml) and the mixture was refluxed under heating for 3 hr 15 min. The solvent was evaporated and ethyl acetate was added. The resulting crystals were collected by filtration. The obtained crystals were dissolved in water (40 ml) and potassium carbonate was added to saturation, and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate and, after drying, the solvent was evaporated under reduced pressure to give the objective 4-(morpholinomethyl)phenylmethylamine (17.4 g), melting point 47-49° C.

후처리

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 3 hr 15 min
  3. customThe solvent was evaporated
  4. additionethyl acetate was added
  5. filtrationThe resulting crystals were collected by filtration
  6. dissolutionThe obtained crystals were dissolved in water (40 ml)
  7. additionpotassium carbonate was added to saturation
  8. extractionthe mixture was extracted with chloroform
  9. dry with materialThe extract was dried over anhydrous sodium sulfate
  10. customafter drying
  11. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e6392a97e6fb4e04b10839553d0aeb70
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288061B1

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