HCID 21703930, compound → HCID 178450800, compound

HRID 1595384Notes

Reaction equation

HRID 1595384 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][NH2:17])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25](=O)[C:26](=[N:34]O)[C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[CH:21][CH:20]=1>N1C=CC=CC=1>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[NH:17][C:16]([C:13]3[CH:12]=[CH:11][C:10]([N:7]4[CH2:6][CH2:5][N:4]([CH2:3][CH2:2][OH:1])[CH2:9][CH2:8]4)=[CH:15][CH:14]=3)=[N:34][C:26]=2[C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 21703930HCID 21703930, compoundHCID 178451307HCID 178451307, compound

Product 1

HCID 178450800HCID 178450800, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-[4-(2-Hydroxyethyl)piperazin-1-yl]phenylmethylamine and tert-butyl 3-(4-chlorophenyl)-2-hydroxyimino-3-oxopropionate are dissolved in pyridine, and the solution is treated in the same manner as in Starting Material Synthetic Example 170 to give the objective tert-butyl 5-(4-chlorophenyl)-2-{4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}imidazole-4-carboxylate.

Workup

  1. additionthe solution is treated in the same manner as

Sources & evidence

ORD record
ord-9557475b081546a08b78299102745fc7
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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