HCID 178522571, compound → HCID 178507447, compound

HRID 1595393Notes

Reaction equation

HRID 1595393 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:11][C:12]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)=[C:13]([C:15]([NH:17][C:18]3[S:19][CH:20]=[CH:21][N:22]=3)=[O:16])[N:14]=2)=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:11][C:12]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:25][CH:24]=3)=[C:13]([C:15]([NH:17][C:18]3[S:19][CH:20]=[CH:21][N:22]=3)=[O:16])[N:14]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 178522571HCID 178522571, compound

Product 1

HCID 178507447HCID 178507447, compoundYield 63.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-(4-Nitrophenyl)-5-(4-trifluoromethylphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (0.42 g) obtained in Example 49 was hydrogenated in methanol using palladium. The catalyst was filtered off and the residue was concentrated to give 2-(4-aminophenyl)-5-(4-trifluoromethylphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide (0.25 g), melting point 175-177° C.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe residue was concentrated

Sources & evidence

ORD record
ord-e8662bcafb114d57af3f8470c654d7d1
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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