HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178522571, compound → HCID 178507447, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178522571 | HCID 178522571 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178507447 | HCID 178507447 | 63.7% |
Reaction Steps
2-(4-Nitrophenyl)-5-(4-trifluoromethylphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (0.42 g) obtained in Example 49 was hydrogenated in methanol using palladium. The catalyst was filtered off and the residue was concentrated to give 2-(4-aminophenyl)-5-(4-trifluoromethylphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide (0.25 g), melting point 175-177° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288061B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-e8662bcafb114d57af3f8470c654d7d1 |
| Source note | uspto-grants-2001_09 |