Hydrochloric Acid → HCID 178448791, compound

HRID 1595423Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[CH:22]=3)=[C:11]([C:13]([NH:15][C:16]3[S:17][CH:18]=[CH:19][N:20]=3)=[O:14])[N:12]=2)=[CH:4][CH:3]=1.Cl>>[CH2:7]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[CH:22]=3)=[C:11]([C:13]([NH:15][C:16]3[S:17][CH:18]=[CH:19][N:20]=3)=[O:14])[N:12]=2)=[CH:4][CH:3]=1)[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 178489907HCID 178489907, compound

Product 1

HCID 178448791HCID 178448791, compoundYield 83.1%

Procedure

2-(4-Aminophenyl)-5-(3-methoxyphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (0.8 g) obtained in Example 155 was treated in the same manner as in Example 74 to give the objective 2-(4-butylaminophenyl)-5-(3-methoxyphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide (0.38 g), melting point 228-231° C. (hydrochloride).

Sources & evidence

ORD record: ord-86fb4e0577894221bea4ff322c93e4f9
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06288061B1

Reaction notes

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