Triphenylphosphine → HCID 178489048, compound

HRID 1595442Notes

Reaction equation

HRID 1595442 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[C:11]([C:13]([NH:15][C:16]3[S:17][CH:18]=[CH:19][N:20]=3)=[O:14])[N:12]=2)=[CH:4][CH:3]=1.[CH3:29][N:30]([CH3:35])[CH2:31][CH2:32][CH2:33]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>>[CH3:29][N:30]([CH3:35])[CH2:31][CH2:32][CH2:33][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[C:11]([C:13]([NH:15][C:16]3[S:17][CH:18]=[CH:19][N:20]=3)=[O:14])[N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 766463-(Dimethylamino)-1-propanolHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 178489047HCID 178489047, compound

Product 1

HCID 178489048HCID 178489048, compound

Procedure

2-(4-Hydroxyphenyl)-5-(4-methoxyphenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide, 3-dimethylaminopropanol, triphenyl-phosphine and diethyl azodicarboxylate are reacted and treated in the same manner as in Example 24 to give 2-(4-(3-dimethylamino-propyloxy)phenyl)-5-(4-methoxyphenyl)-N-(2-thiazolyl)imidazole-4-carboxamide.

Workup

  1. additiontreated in the same manner as in Example 24

Sources & evidence

ORD record
ord-2be8f7675dc3446395c82f56b400165e
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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