反应详情

8.55 g (38 mmole) 4-cyanophenethyl methanesulfonate, 4.64 g (38 mmole) p-hydroxybenzaldehyde and 18.7 g (57 mmole) cesium carbonate in 150 ml acetonitrile was refluxed over night. The salt was filtered off and the solvent evaporated in vacuo. The residue was treated with 2 M sodium hydroxide and dichloromethane. The organic phase was dried and evaporated in vacuo. Purification by chromatography on silica gel using dichloromethane as eluent gave 1.6 g (yield 17%) of 4-[2-(4-formylphenoxy)ethyl]benzonitrile.

1. filtrationThe salt was filtered off
2. customthe solvent evaporated in vacuo
3. additionThe residue was treated with 2 M sodium hydroxide and dichloromethane
4. customThe organic phase was dried
5. customevaporated in vacuo
6. customPurification by chromatography on silica gel