反应详情

温度

140 °C

2.4 g (9.6 mmole) 4-[2-(4-formylphenoxy)ethyl]benzonitrile, 1.4 g (12 mmole) 2,4-thiazolidinedione and 1.96 g (24 mmole) sodium acetate was mixed and heated under vacuum to 140° C. The reaction mixture melted and was after 30 minutes removed from the heat. Water:acetone (2:1) was added and filtration followed by recrystallization in trifluoroacetic acid/acetic acid gave 1.79 g (yield 52%) of 5-(4-[2-(4-cyanophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

1. customremoved from the heat
2. additionWater:acetone (2:1) was added
3. filtrationfiltration
4. customfollowed by recrystallization in trifluoroacetic acid/acetic acid