HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1595477Generated: October 25, 2026
Thiazolidinedione → 5-(4-[2-(4-Cyanophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione
https://huagongshe.com/reaction/1595477
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 4-[2-(4-Formylphenoxy)ethyl]benzonitrile | HCID 22988778 | — |
| Product | 5-(4-[2-(4-Cyanophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione | HCID 53847303 | 53.2% |
Reaction Steps
2.4 g (9.6 mmole) 4-[2-(4-formylphenoxy)ethyl]benzonitrile, 1.4 g (12 mmole) 2,4-thiazolidinedione and 1.96 g (24 mmole) sodium acetate was mixed and heated under vacuum to 140° C. The reaction mixture melted and was after 30 minutes removed from the heat. Water:acetone (2:1) was added and filtration followed by recrystallization in trifluoroacetic acid/acetic acid gave 1.79 g (yield 52%) of 5-(4-[2-(4-cyanophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06288096B1 |
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| Source dataset | uspto-grants-2001_09 |
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| ORD ID | ord-70437b1e1a1e4a7ab8e66660c5e8e332 |
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| Source note | uspto-grants-2001_09 |
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