5-([4-Benzyloxyphenyl]methyl)oxazolidine-2,4-dione → 5-([4-Hydroxyphenyl]methyl)oxazolidine-2,4-dione

HRID 1595479Notes

Reaction equation

HRID 1595479 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]2[O:20][C:19](=[O:21])[NH:18][C:17]2=[O:22])=[CH:11][CH:10]=1)C1C=CC=CC=1>O1CCOCC1.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]2[O:20][C:19](=[O:21])[NH:18][C:17]2=[O:22])=[CH:13][CH:14]=1

Participants

4

Reactant 1

HCID 104473305-([4-Benzyloxyphenyl]methyl)oxazolidine-2,4-dione

Product 1

HCID 103529685-([4-Hydroxyphenyl]methyl)oxazolidine-2,4-dioneYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

2.75 g (9.25 mmole) 5-([4-benzyloxyphenyl]methyl)oxazolidine-2,4-dione was hydrogenated at 50 psi over night in 1,4-dioxan using Pd/C as catalyst to give 1.8 g (yield 94%) of 5-([4-hydroxyphenyl]methyl)oxazolidine-2,4-dione.

Sources & evidence

ORD record
ord-e4330ed7ded746cc88baa728f37b0f4c
Source dataset
uspto-grants-2001_09
Patent number
US06288096B1

Reaction notes

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