反应详情

6.75 g (64 mmole) triethylamine was added to 5 g (14,6 mmole) 4-[2-(4-aminophenyl)ethoxy]benzaldehyde x HCl (containing some ethyl acetate) in dichloromethane. 3.65 g (32 mmole) methanesulfonyl chloride was slowly added at 0° C., and the mixture was stirred over the weekend. A yellow precipitate was filtered off and the filtrate was washed with water. The organic phase was dried (sodium sulfate), filtered and the solvent was evaporated. The residue contained some triethylamine and therefore it was dissolved in dichloromethane and washed with 2 M hydrochloric acid and brine, dried and filtered and the solvent was evaporated to give 1.6 g (yield 34%) of N-{4-[2-(4-formylphenoxy)ethyl]phenyl}methanesulfonamide as a yellow powder.

1. filtrationA yellow precipitate was filtered off
2. washthe filtrate was washed with water
3. dry with materialThe organic phase was dried (sodium sulfate)
4. filtrationfiltered
5. customthe solvent was evaporated
6. dissolutionit was dissolved in dichloromethane
7. washwashed with 2 M hydrochloric acid and brine
8. customdried
9. filtrationfiltered
10. customthe solvent was evaporated