反应详情

55 g (0.305 mole) 2-(4-methylcarbonyloxyphenyl)-1-ethanol and 34.4 g (0.341 mole) triethylamine in 300 ml dichloromethane were cooled on an ice bath. 38.5 g (0.336 mole) methanesulfonyl chloride was slowly added. The ice bath was removed and the mixture was stirred for 3 hours at room temperature. Water was added and the phases were separated. The organic phase was washed with saturated sodium hydrogen bicarbonate and brine, dried (magnesium sulfate), filtered and evaporated in vacuo to give 76.6 g (yield 97%) of 4-(methylcarbonyloxy)phenethyl methanesulfonate.

1. customThe ice bath was removed
2. additionWater was added
3. customthe phases were separated
4. washThe organic phase was washed with saturated sodium hydrogen bicarbonate and brine
5. dry with materialdried (magnesium sulfate)
6. filtrationfiltered
7. customevaporated in vacuo