HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-(4-[2-(4-(2-Propanesulfonyloxy)phenyl)ethoxy]benzylidene)thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thiazolidinedione | HCID 5437 | — |
| Reactant | HCID 21705008 | HCID 21705008 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 5-(4-[2-(4-(2-Propanesulfonyloxy)phenyl)ethoxy]benzylidene)thiazolidine-2,4-dione | HCID 86757378 | 58.6% |
Reaction Steps
1.4 g (4 mmole) 4-[2-(4-formylphenoxy)ethyl]phenyl 2-propanesulfonate, 0.94 (8 mmole) 2,4-thiazolidinedione, 5 drops of piperidine, 6 drops of acetic acid and toluene were refluxed with water separation in a Dean-Stark apparatus. When the starting material was consumed the heat was removed and the formed crystals were recrystallized in water:acetone to give 1.5 g (yield 58.6%) of 5-(4-[2-(4-(2-propanesulfonyloxy)phenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288096B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-c55b2f353c3445c58d1496bff4d4a962 |
| Source note | uspto-grants-2001_09 |