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HRID1595527

反应详情

EQUATION

反应方程式

HRID 1595527 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：Cc1ccccc1
HCID1140

Toluene

C7H8

结构：O=C1CSC(=O)N1
HCID5437

Thiazolidinedione

C3H3NO2S

结构：CC(C)S(=O)(=O)Oc1ccc(CCOc2ccc(C=O)cc2)cc1
HCID21705008

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)S(=O)(=O)Oc1ccc(CCOc2ccc(C=C3SC(=O)NC3=O)cc2)cc1
HCID86757378

未命名化合物

收率 58.6%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CC(=O)O
催化剂HCID176

Acetic Acid

C2H4O2

结构：C1CCNCC1
催化剂HCID8082

Piperidine

C5H11N

结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

1.4 g (4 mmole) 4-[2-(4-formylphenoxy)ethyl]phenyl 2-propanesulfonate, 0.94 (8 mmole) 2,4-thiazolidinedione, 5 drops of piperidine, 6 drops of acetic acid and toluene were refluxed with water separation in a Dean-Stark apparatus. When the starting material was consumed the heat was removed and the formed crystals were recrystallized in water:acetone to give 1.5 g (yield 58.6%) of 5-(4-[2-(4-(2-propanesulfonyloxy)phenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

WORKUP

后处理

  1. customWhen the starting material was consumed the heat
  2. customwas removed
  3. customthe formed crystals were recrystallized in water