反应详情

1 g (3.7 mmole) 4-[2-(4-Methylmercaptophenyl)ethoxy]benzaldehyde, 1.09 (9.25 mmole) 2,4-thiazolidinedione, 5 drops of piperidine, 6 drops of acetic acid and toluene were refluxed with water separation in a Dean-Stark apparatus for 1 hour. The heat was removed and the crystals were recrystallized in dichloromethane:methanol (95:5) to give 1.1 g (yield 80%) of 5-(4-[2-(4-methylmercaptophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

1. customThe heat was removed
2. customthe crystals were recrystallized in dichloromethane:methanol (95:5)