Triethylamine → HCID 21704987, compound

HRID 1595543Notes

Reaction equation

HRID 1595543 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=1)[CH2:10][CH2:11][OH:12].C(N(CC)CC)C>ClCCl>[CH3:1][S:2]([O:12][CH2:11][CH2:10][C:9]1[CH:13]=[CH:14][CH:15]=[C:7]([O:6][S:2]([CH3:1])(=[O:4])=[O:3])[CH:8]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 834043-Hydroxyphenethyl alcohol

Product 1

HCID 21704987HCID 21704987, compoundYield 87.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9.09 g (79.6 mmole) methanesulfonyl chloride was slowly added to a solution of 5 g (36.2 mmole) 3-hydroxyphenethyl alcohol and 9.14 g (90.5 mmole) triethylamine in 150 ml dichloromethane at 0° C. After stirring at room temperature over night the salts were filtered off, the organic phase was washed with sodium bicarbonate and brine, dried (magnesium sulfate) and evaporated in vacuo to give 9.3 g (yield 87%) of 3-(methylsulfonyloxy)phenethyl methanesulfonate.

Workup

  1. filtrationwere filtered off
  2. washthe organic phase was washed with sodium bicarbonate and brine
  3. dry with materialdried (magnesium sulfate)
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-03b3315ceb9149d6bc38ba085dfa21fb
Source dataset
uspto-grants-2001_09
Patent number
US06288096B1

Reaction notes

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