反应详情

To stirred solution of (4-Hydroxy-phenylsulfanyl)-acetic acid ethyl ester (2.12 g, 10 mmol), K2CO3 (anhydrous, 10 g) and 1-bromo-3-methyl butane (3 g, excess) was added in boiling acetone. The reaction mixture was refluxed for 24 hrs and cooled to room temperature. The reaction mixture was filtered and concentrated. The residue obtained was extracted with chloroform; washed well with water and concentrated. The crude product obtained was taken to next step with out purification. Yield 2.7 g (94%); (M+H)+283.

1. additionwas added
2. temperatureThe reaction mixture was refluxed for 24 hrs
3. filtrationThe reaction mixture was filtered
4. concentrationconcentrated
5. customThe residue obtained
6. extractionwas extracted with chloroform
7. washwashed well with water
8. concentrationconcentrated