反应详情

温度

205 °C

A reaction mixture of 1.74 g (5.52 mmol) of 4-(1H-Indazol-6-ylamino)-7-methoxy-quinoline-3-carbonitrile and 15.3 g of pyridine hydrochloride was heated at 200-210° C. for 1.5 hr. After cooling, the mixture was taken into 3% NH4OH aqueous solution. The precipitate was collected by filtration and washed with water. Drying in vacuo afforded 1.66 g (63.8%) of the product as deep brown solid, m.p.>250° C., mass (electrospray, m/e): M+H 301.9. HRCIMS: calcd 302.1042 for C17H11N5O (M+) obsd 302.1079.

1. temperatureAfter cooling
2. filtrationThe precipitate was collected by filtration
3. washwashed with water
4. customDrying in vacuo