Pyridinium chloride → HCID 178486708, compound

HRID 1595814Notes

Reaction equation

HRID 1595814 reaction equation
[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](Cl)=[C:10]([C:15]#[N:16])[CH:11]=[N:12]2)=[CH:7][C:6]=1[O:18][CH3:19].[NH2:20][C:21]1[CH:29]=[CH:28][C:24]2[NH:25][N:26]=[N:27][C:23]=2[CH:22]=1.Cl.N1C=CC=CC=1>COCCO>[N:25]1[C:24]2[CH:28]=[CH:29][C:21]([NH:20][C:9]3[C:8]4[C:13](=[CH:14][C:5]([O:4][CH2:3][CH2:2][Cl:1])=[C:6]([O:18][CH3:19])[CH:7]=4)[N:12]=[CH:11][C:10]=3[C:15]#[N:16])=[CH:22][C:23]=2[NH:27][N:26]=1

Participants

5

Reactant 3

HCID 10176127Pyridinium chlorideHCID 111092524-Chloro-7-(2-chloroethoxy)-6-methoxy-3-quinolinecarbonitrileHCID 178507366HCID 178507366, compound

Product 1

HCID 178486708HCID 178486708, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

The title compound was prepared by the procedure of Example 166 using 0.442 g of 7-(2-chloro-ethoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile, 0.22 g 5-amino benzotriazole, 0.190 g of pyridine hydrochloride and 15 ml of 2-methoxyethanol to give 0.48 g (82%) of the desired product :mass spectrum (electrospray m/e): M+H=394.8.

Sources & evidence

ORD record
ord-3866c0f60cc44e098a124798d7d92718
Source dataset
uspto-grants-2001_09
Patent number
US06288082B1

Reaction notes

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