1H-Indazol-6-amine → HCID 10223129, compound

HRID 1595815Notes

Reaction equation

HRID 1595815 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10](Cl)=[C:11]([C:16]#[N:17])[CH:12]=[N:13]2)=[CH:8][C:7]=1[O:19][CH3:20].[CH:21]1[C:26]([NH2:27])=[CH:25][C:24]2[NH:28][N:29]=[CH:30][C:23]=2[CH:22]=1.Cl.N1C=CC=CC=1.C(OC(O)C)C>>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[C:14]2[C:9]([C:10]([NH:27][C:26]3[CH:25]=[C:24]4[C:23]([CH:30]=[N:29][NH:28]4)=[CH:22][CH:21]=3)=[C:11]([C:16]#[N:17])[CH:12]=[N:13]2)=[CH:8][C:7]=1[O:19][CH3:20]

Participants

5

Reactant 4

HCID 814231H-Indazol-6-amineHCID 101298981-EthoxyethanolHCID 10176127Pyridinium chlorideHCID 112206374-Chloro-7-(3-chloropropoxy)-6-methoxyquinoline-3-carbonitrile

Product 1

HCID 10223129HCID 10223129, compoundYield 90%

Procedure

The title compound was prepared by the procedure of Example 166 using 0.311 g of 7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile, 0.147 g of 6-aminoimidazole, 0.128 g of pyridine hydrochloride and 12 ml of ethoxyethanol to give 0.367 g (90%) of the desired product. MP 280-285° C. mass spectrum (electrospray m/e): M+H=407.9.

Sources & evidence

ORD record
ord-6d5b386feb8745bcbb81926dc7c5af88
Source dataset
uspto-grants-2001_09
Patent number
US06288082B1

Reaction notes

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