Dibutyltin oxide → HCID 178505094, compound

HRID 1595827Notes

Reaction equation

HRID 1595827 reaction equation
C[Si]([N:5]=[N+:6]=[N-:7])(C)C.C([Sn](=O)CCCC)CCC.[C:18]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]([CH2:31]/[CH:32]=[CH:33]/[C:34]1[CH:39]=[C:38]([Cl:40])[CH:37]=[C:36]([Cl:41])[CH:35]=1)[S:27]([CH3:30])(=[O:29])=[O:28])#[N:19]>C1(C)C=CC=CC=1.C(Cl)Cl>[Cl:41][C:36]1[CH:35]=[C:34](/[CH:33]=[CH:32]/[CH2:31][N:26]([CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][C:18]2[NH:19][N:7]=[N:6][N:5]=2)[S:27]([CH3:30])(=[O:29])=[O:28])[CH:39]=[C:38]([Cl:40])[CH:37]=1

Participants

6

Reactant 3

HCID 61221Dibutyltin oxideHCID 78378AzidotrimethylsilaneHCID 22246898HCID 22246898, compound

Product 1

HCID 178505094HCID 178505094, compoundYield 53.4%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

Trimethylsilylazide (0.136 mL, 1.026 mmol) and dibutyltinoxide (38 mg, 0.15 mmol) were added to a solution of trans-N-(6-cyano-hexyl)-N-[3-(3,5-dichloro-phenyl)-allyl]-methanesulfonamide (59A) (199 mg, 0.52 mmol) in toluene (4 mL). The reaction was heated at reflux overnight. The reaction was diluted with CH2Cl2 and the organic solution was washed sequentially with HCl(1N, 1×), water (1×), and brine (1×). The organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The product was purified via radial chromatography (CH2Cl2 to 5% MeOH/CH2Cl2) to afford the title compound (120 mg). 1H NMR (CDCl3 400 MHz) δ 7.26 (m, 3H), 6.50 (d, 1H), 6.22 (m, 1H), 4.00 (m, 2H), 3.23 (t, 2H), 3.02 (t, 2H), 2.90 (s, 3H), 1.83 (t, 2H), 1.62 (t, 2H), 1.38 (m, 4H); MS 132 (M+).

Workup

  1. temperatureThe reaction was heated
  2. temperatureat reflux overnight
  3. washthe organic solution was washed sequentially with HCl(1N, 1×), water (1×), and brine (1×)
  4. dry with materialThe organic solution was dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe product was purified via radial chromatography (CH2Cl2 to 5% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-e50a5d54246d487e81442f9dde71e165
Source dataset
uspto-grants-2001_09
Patent number
US06288120B1

Reaction notes

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