Hydrochloric Acid → 3-Amino-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester hydrochloride

HRID 1596017Notes

Reaction equation

HRID 1596017 reaction equation
[CH2:1]([O:8][C:9]([C:11]1([N:19]=C(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:17][CH:16]2[O:18][CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>C(OCC)C>[ClH:33].[CH2:1]([O:8][C:9]([C:11]1([NH2:19])[CH2:17][CH:16]2[O:18][CH:13]([CH2:14][CH2:15]2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 540516143-(Benzhydrylideneamino)-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester

Product 1

HCID 699219873-Amino-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A two-phase mixture of 3-(benzhydrylideneamino)-8-oxabicyclo[3.2.1]octane-3-carboxylic acid benzyl ester (3.9 mmole) in aqueous 1N hydrochloric acid solution (100 mL.) and diethyl ether (100 mL) is stirred at room temperature overnight. The aqueous layer ifs concentrated to provide the title compound.

Workup

  1. concentrationThe aqueous layer ifs concentrated

Sources & evidence

ORD record
ord-d85800a1750644d6b400fdc13c9afeea
Source dataset
uspto-grants-2001_09
Patent number
US06288246B1

Reaction notes

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