Tetrahydrofuran → HCID 21701035, compound

HRID 1596125Notes

Reaction equation

HRID 1596125 reaction equation
[C:1]([O:5][CH2:6][CH2:7][CH2:8][OH:9])(=[O:4])[CH:2]=[CH2:3].[S:10]1C=CC=C1.O1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:3]12[S:10][CH:17]([CH:18]=[CH:19]1)[CH2:16][CH:2]2[C:1]([O:5][CH2:6][CH2:7][CH2:8][OH:9])=[O:4]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8030ThiopheneHCID 331012-Propenoic acid, 3-hydroxypropyl ester

Product 1

HCID 21701035HCID 21701035, compound

Conditions

Temperature
70 °C

Procedure

Tetrahydrofuran solvent (500 g), 3-hydroxypropyl acrylate (1.2 mole) of Chemical Formula 3b below, and thiophene (1.0 mole) are introduced to a 2-liter flask, and the mixture is stirred at 70° C. for 24 hours. After the reaction is completed, the solvent and excess amount of 3-hydroxypropyl acrylate were removed by using a rotary evaporator. The residue is distilled in vacuo to obtain pure 3-hydroxypropyl 7-thiabicyclo[2.2.1]hept-5-ene-2-carboxylate represented by Chemical Formula 109 (yield: 80%).

Workup

  1. customthe solvent and excess amount of 3-hydroxypropyl acrylate were removed
  2. customa rotary evaporator
  3. distillationThe residue is distilled in vacuo

Sources & evidence

ORD record
ord-0d46ed8984f3448e9cd5b684e723d706
Source dataset
uspto-grants-2001_09
Patent number
US06291131B1

Reaction notes

Loading…