Tetrahydrofuran → HCID 21701036, compound

HRID 1596126Notes

Reaction equation

HRID 1596126 reaction equation
[C:1]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])(=[O:4])[CH:2]=[CH2:3].[S:10]1C=CC=C1.O1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:3]12[S:10][CH:17]([CH:18]=[CH:19]1)[CH2:16][CH:2]2[C:1]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 8030ThiopheneHCID 15458tert-Butyl acrylate

Product 1

HCID 21701036HCID 21701036, compoundYield 80%

Conditions

Temperature
70 °C

Procedure

Tetrahydrofuran solvent (500 g), tert-butyl acrylate (1.2 mole) of Chemical Formula 3c below, and thiophene (1.0 mole) are introduced into a 2-liter flask, and the mixture is stirred at 70° C. for 24 hours. After the reaction is completed, the solvent and excess amount of tert-butyl acrylate are removed by using a rotary evaporator. The residue is distilled in vacuo to obtain pure tert-butyl 7-thiabicyclo[2.2.1]hept-5-ene-2-carboxylate represented by Chemical Formula 117 below (yield: 80%).

Workup

  1. customthe solvent and excess amount of tert-butyl acrylate are removed
  2. customa rotary evaporator
  3. distillationThe residue is distilled in vacuo

Sources & evidence

ORD record
ord-1b7dae878c244e7f988e76e3df013358
Source dataset
uspto-grants-2001_09
Patent number
US06291131B1

Reaction notes

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