Hydrochloric Acid → 7-Thiabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid

HRID 1596131Notes

Reaction equation

HRID 1596131 reaction equation
[CH:1]12[S:7][CH:4]([CH:5]=[CH:6]1)[CH:3]1[C:8]([O:10][C:11](=[O:12])[CH:2]21)=[O:9].Cl.[OH2:14]>>[CH:1]12[S:7][CH:4]([CH:5]=[CH:6]1)[CH:3]([C:8]([OH:14])=[O:9])[CH:2]2[C:11]([OH:10])=[O:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 556018HCID 556018, compound

Product 1

HCID 217010347-Thiabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid

Conditions

Temperature
700 °C

Procedure

The compound of Chemical Formula 201, that is 7-thiabicyclo[2.2.1]hept-5ene-2,3-dicarboxylic anhydride (50 g) is well mixed with water (200 ml), and 1 g of hydrochloric acid is added thereto. The resultant mixture is heated under reflux at 700° C. for 20 hours. Upon cooling the mixture to room temperature, crystals are formed. The crystals are dried in vacuo to obtain 7-thiabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid represented by Chemical Formula 167 (yield: 70%).

Workup

  1. additionis added
  2. temperatureUpon cooling the mixture to room temperature
  3. customcrystals are formed
  4. customThe crystals are dried in vacuo

Sources & evidence

ORD record
ord-ebfafd000ecd4837ab6553eef872ff62
Source dataset
uspto-grants-2001_09
Patent number
US06291131B1

Reaction notes

Loading…