反应详情

温度

50 °C

To a stirred solution of (S)-1-tert-butoxycarbonyl-2-methyl-4-benzylpiperazine (864 mg) in methanol (5 ml) was added concentrated hydrochloric acid (0.94 ml). The reaction mixture was stirred at 50° C. for 1 hour. After cooling, the solvent was evaporated off. The residue was made to alkali with 1N aqueous solution of sodium hydroxide and extracted with ethyl acetate (×3). The combined organic layer was dried over magnesium sulfate and concentrated to give (S)-1-benzyl-3-methylpiperazine (588 mg).

1. temperatureAfter cooling
2. customthe solvent was evaporated off
3. extractionextracted with ethyl acetate (×3)
4. dry with materialThe combined organic layer was dried over magnesium sulfate
5. concentrationconcentrated