反应详情

To a stirred solution of (S)-1-benzyl-3-methylpiperazine (588 mg) and triethylamine (0.47 ml) in dichloromethane (5 ml) was added acetic anhydride (0.32 ml) at 0° C. The reaction mixture was stirred at ambient temperature for 4 hours. Methanol was added to this solution and evaporated. The residue was taken up in ethyl acetate and washed with water and brine. The organic layer was dried over magnesium sulfate and concentrated. The residue was purified by column chromatography eluting with a mixture of ethyl acetate and n-hexane (2:1) to give (S)-1-acetyl-4-benzyl-2-methylpiperazine (660 mg).

1. customevaporated
2. washwashed with water and brine
3. dry with materialThe organic layer was dried over magnesium sulfate
4. concentrationconcentrated
5. customThe residue was purified by column chromatography
6. washeluting with a mixture of ethyl acetate and n-hexane (2:1)