(S)-1-Acetyl-2-methyl-4-benzylpiperazine → (2S)-N-acetyl-2-methylpiperazine

Participants

Reaction Steps

(S)-1-Acetyl-2-methyl-4-benzylpiperazine (1.87 g) was hydrogenated over palladium hydroxide (600 mg) at ambient temperature for 3 hours. The catalyst was filtered off and the solvent was evaporated off. The residue was purified by column chromatography eluting with a mixture of methanol and chloroform (1:5) to give 440 mg of (S)-1-acetyl-2-methylpiperazine (440 mg).

Provenance & Evidence