Anisole → HCID 21701628, compound

HRID 1596220Notes

Reaction equation

HRID 1596220 reaction equation
C1(OC)C=CC=CC=1.C(OC([N:19]1[CH2:24][CH2:23][N:22]([NH:25][C:26](=[O:34])[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH2:21][CH2:20]1)=O)C1C=CC=CC=1.[BrH:35].C(O)(=O)C>>[BrH:35].[N:22]1([NH:25][C:26](=[O:34])[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH2:21][CH2:20][NH:19][CH2:24][CH2:23]1

Participants

4

Reactant 3

HCID 7519AnisoleHCID 9928674Phenylmethyl 4-[(4-fluorobenzoyl)amino]-1-piperazinecarboxylateHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 21701628HCID 21701628, compound

Procedure

To a solution of 25% hydrogen bromide-acetic acid (30 ml) and anisole (1.6 ml) was added N-(4-benzyloxycarbonyl-1-piperazinyl)-p-fluorobenzamide (10 g) dropwise for 15 minutes under nitrogen atmosphere. The reaction mixture was stirred at ambient temperature for 3 hours. The resulting precipitate was collected and washed with diethyl ether (10 ml) to give N-piperazinyl-p-fluorobenzamide hydrobromide (10.2 g) as white hydroscopic solid.

Workup

  1. customThe resulting precipitate was collected
  2. washwashed with diethyl ether (10 ml)

Sources & evidence

ORD record
ord-9674627e387f462785a1c29b08a5e111
Source dataset
uspto-grants-2001_09
Patent number
US06291464B1

Reaction notes

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