反应详情

To a stirred solution of (S)-1-acetyl-4-amino-2-methylpiperazine (320 mg) and triethylamine (0.57 ml) in dichloromethane (10 ml) was added 4-fluorobenzoyl chloride (0.27 ml) at 0° C. The mixture was stirred at ambient temperature for 3 hours, washed with water and brine. The organic layer was dried over magnesium sulfate, and concentrated. The residue was purified by column chromatography eluting with a mixture of methanol and chloroform (1:9) to give (S)-N-(4-acetyl-2-methyl-1-piperazinyl)-4-fluorobenzamide (50 mg).

1. washwashed with water and brine
2. dry with materialThe organic layer was dried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was purified by column chromatography
5. washeluting with a mixture of methanol and chloroform (1:9)