Phenyl isocyanate → HCID 21701638, compound

HRID 1596230Notes

Reaction equation

HRID 1596230 reaction equation
Br.[N:2]1([NH:8][C:9](=[O:17])[C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[C:25]1([N:31]=[C:32]=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>ClCCl>[C:25]1([NH:31][C:32]([N:5]2[CH2:4][CH2:3][N:2]([NH:8][C:9](=[O:17])[C:10]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[CH2:7][CH2:6]2)=[O:33])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

5

Reactant 3

HCID 7672Phenyl isocyanateHCID 8471TriethylamineHCID 21701628HCID 21701628, compound

Product 1

HCID 21701638HCID 21701638, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of N-piperazinyl-p-fluorobenzamide hydrobromide (300 mg) and triethylamine (0.412 ml) in dichloromethane (6 ml) was added phenyl isocyanate (0.186 ml) at ambient temperature, and the reaction mixture was stirred at the same temperature for 1 hour. The precipitate was filtered, then washed with dichloromethane and water. The residue was dried to give N-(4-phenylcarbamoyl-1-piperazinyl)-p-fluorobenzamide (0.23 g).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with dichloromethane and water
  3. customThe residue was dried

Sources & evidence

ORD record
ord-1e3a9dec8d6d4e4c80a18e1064495ed2
Source dataset
uspto-grants-2001_09
Patent number
US06291464B1

Reaction notes

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