Hydrochloric Acid → HCID 21701721, compound

HRID 1596302Notes

Reaction equation

HRID 1596302 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH:14]=[C:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22676694N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine

Product 1

HCID 21701721HCID 21701721, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 55.00 g of N-t-butoxycarbonyl-4-(4-fluorobenzylidene)piperidine was added 475 ml of an ice-cooled solution of 4 N hydrogen chloride in dioxane, followed by stirring at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, and the resulting crystals were recrystallized from isopropanol to give 40.72 g of 4-(4-fluorobenzylidene)piperidine hydrochloride.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customthe resulting crystals were recrystallized from isopropanol

Sources & evidence

ORD record
ord-ac69b32e7d1141169a32c31812846790
Source dataset
uspto-grants-2001_09
Patent number
US06291467B1

Reaction notes

Loading…