反应详情

Intermediate 21 (18.2 g) was added to a solution of KOH (37.6 g) in water (380 ml). The resulting reaction mixture was stirred and refluxed for 3 hours. The mixture was cooled, acidified with hydrochloric acid, and the resulting precipitate was filtered off, washed with water, suspended in ACN, filtered off, then dried, yielding 14 g (>95%) of 7-amino-6-chloro-1,3-benzodioxole-4-carboxylic acid (intermediate 22).

1. customThe resulting reaction mixture
2. temperaturerefluxed for 3 hours
3. temperatureThe mixture was cooled
4. filtrationthe resulting precipitate was filtered off
5. washwashed with water
6. filtrationfiltered off
7. customdried