反应详情

NaOH (6.0 mL; 10M), H2O (10 mL) and iso-propylchloroformate (55 mmol) were added to a solution of 3-benzyl-3,7-diazabicyclo[3.3.1]nonane (10.8 g; 50 mmol; see Example E above)-in DCM (50 mL) The reaction mixture was stirred for 3 h and the phases were then separated. The organic phase -was washed with H2O and brine, dried and concentrated to give the sub-title compound in a 95% yield.

1. customthe phases were then separated
2. washThe organic phase -was washed with H2O and brine
3. customdried
4. concentrationconcentrated