HCID 131722854, compound → HCID 86757397, compound

HRID 1596437Notes

Reaction equation

HRID 1596437 reaction equation
C([N:8]1[CH2:15][CH:14]2[CH2:16][CH:10]([CH2:11][N:12]([C:17]([O:19][C:20]([CH2:23][CH3:24])([CH3:22])[CH3:21])=[O:18])[CH2:13]2)[CH2:9]1)C1C=CC=CC=1>CCO.[Pd]>[CH:14]12[CH2:16][CH:10]([CH2:9][NH:8][CH2:15]1)[CH2:11][N:12]([C:17]([O:19][C:20]([CH2:23][CH3:24])([CH3:21])[CH3:22])=[O:18])[CH2:13]2

Participants

4

Reactant 1

HCID 131722854HCID 131722854, compound

Product 1

HCID 86757397HCID 86757397, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 23938PalladiumSolvent

Procedure

tert-Pentyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (8.67 g; from step (a) above) was dissolved in EtOH (45 mL) and hydrogenated over 5% Pd/C at 1 atm. for 10 h. The catalyst was removed by filtration and the residue was concentrated giving the sub-title compound.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe residue was concentrated

Sources & evidence

ORD record
ord-bb84853e3e904d1999ba81b522a561b4
Source dataset
uspto-grants-2001_09
Patent number
US06291475B1

Reaction notes

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