反应详情

Acryloyl chloride (28.5 mL; 350 mmol) was added to a stirred solution of phenylamine (30 mL; 320 mmol) and TEA (56 mL; 400 mmol) in THF (1 L) at 0° C. The reaction mixture was stirred for 3 h, poured onto brine and extracted with diethyl ether. The organic layer was dried, concentrated and recrystallized from hexane:EtOAc (3:1) to give the sub-title compound in a 79% yield.

1. additionpoured onto brine
2. extractionextracted with diethyl ether
3. customThe organic layer was dried
4. concentrationconcentrated
5. customrecrystallized from hexane:EtOAc (3:1)