Pyridine → HCID 21701929, compound

HRID 1596452Notes

Reaction equation

HRID 1596452 reaction equation
[Cl:1][CH2:2][CH2:3][C:4](Cl)=[O:5].[C:7]([C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=1)#[N:8].N1C=CC=CC=1>C(Cl)Cl>[C:7]([C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:4](=[O:5])[CH2:3][CH2:2][Cl:1])=[CH:11][CH:10]=1)#[N:8]

Participants

5

Reactant 3

HCID 1049PyridineHCID 133964-AminobenzonitrileHCID 693643-Chloropropionyl chloride

Product 1

HCID 21701929HCID 21701929, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Chloropropionylchloride (1.08 g; 8.5 mmol) was added to a cooled (10° C.) solution of 4-cyanoaniline (1.0 g; 8.5 mmol) and pyridine (0.69 mL; 8.5 mnol) in DCM (40 mL), and the reaction mixture was stirred at rt. for 1 h. The reaction mixture was extracted with HCl (2N), washed with water, dried and concentrated to give the sub-title compound in a 81% yield.

Workup

  1. extractionThe reaction mixture was extracted with HCl (2N)
  2. washwashed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-f9df6f4f87784751b0bb5343033247dd
Source dataset
uspto-grants-2001_09
Patent number
US06291475B1

Reaction notes

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