Water → HCID 54360993, compound

HRID 1596476Notes

Reaction equation

HRID 1596476 reaction equation
[S:1](Cl)([CH3:4])(=[O:3])=[O:2].[C:6]([C:8]1[CH:19]=[CH:18][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][OH:17])=[CH:10][CH:9]=1)#[N:7].O>C(Cl)Cl>[C:6]([C:8]1[CH:19]=[CH:18][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][S:1]([CH3:4])(=[O:3])=[O:2])=[CH:10][CH:9]=1)#[N:7]

Participants

5

Reactant 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 13423053HCID 13423053, compound

Product 1

HCID 54360993HCID 54360993, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Mesylchloride (2.32 mL; 30 mmol) was added to a stirred 0° C. solution of 4-(4-cyanophenoxy)-1-butanol (5.2 g; 29.7 mmol; from step (c) above) and TEA (4.35 mL) in CH2Cl2 (50 mL), and the reaction mixture was stirred for 4 h. H2O (150 mL) was added and the organic layer separated, dried and concentrated to give the sub-title compound which was used without further purification.

Workup

  1. customthe organic layer separated
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-76373fb0bd4748ea81d6acf5f02fac13
Source dataset
uspto-grants-2001_09
Patent number
US06291475B1

Reaction notes

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