1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 1596479Notes

Reaction equation

HRID 1596479 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[OH:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>C(Cl)Cl>[OH:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][N:14]([C:5](=[O:7])[CH3:6])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

Product 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetic acid anhydride (5.1 g; 50 mmol) was added to a stirred solution of N-(2-hydroxyethyl)piperazine (6.5 g; 50 mmol) in DCM (5 mL). The reaction mixture was stirred until the exothermic reaction was complete. The solvent was evaporated and the residue co-evaporated with toluene. The crude sub-title compound was used without further purification.

Workup

  1. customThe solvent was evaporated
  2. customThe crude sub-title compound was used without further purification

Sources & evidence

ORD record
ord-e34f07aa28c847ba8d101592d520e1d3
Source dataset
uspto-grants-2001_09
Patent number
US06291475B1

Reaction notes

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