Ethanethiol → HCID 21702000, compound

HRID 1596494Notes

Reaction equation

HRID 1596494 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]([O:30]C)[CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]C)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:32]3[CH:37]=[CH:36][C:35]([O:38]C)=[CH:34][CH:33]=3)[S:8][C:7]=2[CH:40]=1.C(S)C.[Cl-].[Al+3].[Cl-].[Cl-]>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH:21]([OH:30])[CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[CH:17][CH:18]=3)=[O:12])=[C:9]([C:32]3[CH:33]=[CH:34][C:35]([OH:38])=[CH:36][CH:37]=3)[S:8][C:7]=2[CH:40]=1

Participants

4

Reactant 3

HCID 6343EthanethiolHCID 6451240Aluminum(III) ChlorideHCID 21702023HCID 21702023, compound

Product 1

HCID 21702000HCID 21702000, compoundYield 63.8%

Procedure

[6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-(2-methoxy-3-hexylaminopropoxy)phenyl]methanone (340 mg, 0.62 mmol) was converted to 200 mg of the title compound by the procedure of Example 32 using 0.23 mL (3.1 mmol) of ethanethiol 660 mg (5.0 mmol) of aluminum chloride.

Sources & evidence

ORD record
ord-b3f54468eebc477782374d5a06833abf
Source dataset
uspto-grants-2001_09
Patent number
US06291484B1

Reaction notes

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