Hydrochloric Acid → Ethyl 3-amino-3-(3-nitrophenyl)propanoate hydrochloride

HRID 1596558Notes

Reaction equation

HRID 1596558 reaction equation
[ClH:1].[NH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[CH2:4][C:5]([OH:7])=[O:6].Cl.[CH2:18](O)[CH3:19]>>[ClH:1].[NH2:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[CH2:4][C:5]([O:7][CH2:18][CH3:19])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 28682063-Amino-3-(3-nitrophenyl)-propionic acid hydrochloride

Product 1

HCID 16188861Ethyl 3-amino-3-(3-nitrophenyl)propanoate hydrochloride

Procedure

60 g of (1a) were suspended in 660 ml of ethanol, and gaseous HCl was passed in for 1 h. The reaction mixture was then heated under reflux for 4 h and then cooled and concentrated. 62 g of a white solid were obtained.

Workup

  1. customwas passed in for 1 h
  2. temperatureThe reaction mixture was then heated
  3. temperatureunder reflux for 4 h
  4. temperaturecooled
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-178b0107adaf481685f4527ecb81e4df
Source dataset
uspto-grants-2001_09
Patent number
US06291503B1

Reaction notes

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