Hexane → HCID 21702555, compound

HRID 1596618Notes

Reaction equation

HRID 1596618 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH2:9][CH2:10][C:11](=[O:13])[CH3:12])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].CCCCCC>O>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH2:9][CH2:10][C:11](=[O:13])[CH:12]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 8058HexaneHCID 14798Sodium HydroxideHCID 21702494HCID 21702494, compound

Product 1

HCID 21702555HCID 21702555, compoundYield 42,568.398%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

1-(3-Fluorophenyl)-1,4-pentandione (23 g, 0.12 mmol) was dissolved in water (550 ml) containing 11 g of sodium hydroxide and the solution was stirred at 100° C. for 3 hours. After cooling to 0° C. the resultant brown crystals were collected by filtration and washed with water. The title compound (9 g, 45% yield) was obtained by recrystallization from hexane as a yellow solid.

Workup

  1. temperatureAfter cooling to 0° C. the resultant brown crystals
  2. filtrationwere collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-48cff1d21022410d9fe8ec42a01f1a89
Source dataset
uspto-grants-2001_09
Patent number
US06291520B1

Reaction notes

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