HCID 69843012, compound → HCID 86757405, compound

HRID 1596689Notes

Reaction equation

HRID 1596689 reaction equation
F[C:2](F)(F)[C:3]([OH:5])=[O:4].[N:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][N:16]2[CH2:32][CH2:31][C:19]3([CH2:24][C:23](=[O:25])[N:22]([CH2:26][C:27]([OH:29])=[O:28])[C:21](=[O:30])[CH2:20]3)[CH2:18][CH2:17]2)=[CH:10][CH:9]=1>C(O)(=O)C.O=[Pt]=O>[C:3]([OH:5])(=[O:4])[CH3:2].[C:27]([OH:29])(=[O:28])[CH3:26].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][C:19]3([CH2:24][C:23](=[O:25])[N:22]([CH2:26][C:27]([OH:29])=[O:28])[C:21](=[O:30])[CH2:20]3)[CH2:31][CH2:32]2)[CH2:10][CH2:9]1

Participants

4

Reactant 1

HCID 69843012HCID 69843012, compound

Product 1

HCID 86757405HCID 86757405, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 176Acetic AcidSolvent

Procedure

To a solution of 0.5 g (1.25 mmol) of the compound from Example 26. Step C in 40 ml 90% acetic acid were added 100 mg PtO2. The mixture was filled into an autoclave and hydrogenated at 20 atm and room temperature for 22 h. The solvent was removed under reduced pressure, and the residue was stirred with ether. The insoluble title compound was separated and dried in vacuo.

Workup

  1. additionThe mixture was filled into an autoclave and hydrogenated at 20 atm and room temperature for 22 h
  2. customThe solvent was removed under reduced pressure
  3. customThe insoluble title compound was separated
  4. customdried in vacuo

Sources & evidence

ORD record
ord-6af467554e3e410982d74d2eec737bda
Source dataset
uspto-grants-2001_09
Patent number
US06291469B1

Reaction notes

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