HCID 53772014, compound → HCID 53876066, compound

HRID 1596720Notes

Reaction equation

HRID 1596720 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:19]CC2C=CC=CC=2)=[C:8]([CH:18]=1)[O:9][CH2:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])(=[O:3])[CH3:2]>CCO.[Pd]>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([OH:19])=[C:8]([CH:18]=1)[O:9][CH2:10][C:11]([O:13][C:14]([CH3:16])([CH3:15])[CH3:17])=[O:12])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 53772014HCID 53772014, compound

Product 1

HCID 53876066HCID 53876066, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of t-butyl (5-acetyl-2-benzyloxyphenoxy)-acetate (2.0 g, 5.6 mmol) in EtOH (25 mL) is added 10% Pd/C (0.10 g), and the mixture is hydrogenated at 1 atm for 1.25 hours. Filtration through celite, followed by solvent removal in vacuo yields t-butyl (5-acetyl-2-hydroxyphenoxy)-acetate.

Workup

  1. filtrationFiltration through celite
  2. customfollowed by solvent removal in vacuo

Sources & evidence

ORD record
ord-1c4a729683c04f80949545b27ff8b3f5
Source dataset
uspto-grants-2001_09
Patent number
US06291530B1

Reaction notes

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